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UGent lecture: 'The immune signature reveals a pro-tumor role for neutrophils in a mouse model of lung adenocarcinoma'

Dr. Etienne Meylan (Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences (SV),Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland) will present his recent work.

Lung cancer is the leading cause of cancer-related deaths worldwide in women and men, with adenocarcinoma representing the main histological subtype. The goal of the research of our laboratory is to understand how lung tumors grow and progress to a lethal disease. We focus on immune and metabolic aspects of tumors, whose alterations could influence tumor development profoundly. To study these crucial aspects of tumor growth, we are using genetically-engineered mouse models, complemented by in vitro and bioinformatics approaches, as well as human tumor tissue analyses. Here, I will present our recent data obtained upon exhaustive extraction and analysis of tumor-associated immune cells from a mouse model of lung adenocarcinoma. Multi-parameter flow cytometry combined with unbiased analyses enabled to identify immune signatures clustering tumors in function of their aggressiveness, immunogenicity or prior chemotherapy treatment. Additionally, our results highlighted neutrophils as an important immune cell type in lung tumors. During this talk I will discuss our experimental approaches and the involvement of neutrophils in lung adenocarcinoma progression.